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When the UPR fails to clear misfolded proteins through proteasomal degradation, cells are unable to resolve ER stress, leading to apoptosis and subsequent degradation of TM tissue

Cell 151 (6), 12561269

Martnez-Gonzlez L et al

IFD-1 and IFD-2 also act in proteostressed neurons to mediate efficient extrusion of cytoplasmic contents in large exopher vesicles (Summary in Supplementary Fig